Fragmentation of human polymorphonuclear-leucocyte collagenase

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Fragmentation of human polymorphonuclear-leucocyte collagenase.

Human polymorphonuclear-leucocyte collagenase (M(r) 64,000) shows autoproteolytic degradation to two major fragments of M(r) 40,000 and M(r) 27,000. N-terminal sequence data and investigation of the substrate specificity of the fragments demonstrate that the M(r)-40,000 fragment corresponds to the catalytic domain, whereas the M(r0-27,000 fragment shows no enzymic activity. The activity profile...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1993

ISSN: 0264-6021,1470-8728

DOI: 10.1042/bj2910847